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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKDC All Species: 25.45
Human Site: T3268 Identified Species: 62.22
UniProt: P78527 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78527 NP_001075109.1 4128 469089 T3268 E L H K E S K T R D D W L V S
Chimpanzee Pan troglodytes XP_001147162 4128 468882 T3268 E L H K E S K T R D D W L V S
Rhesus Macaque Macaca mulatta XP_001100610 4128 469402 T3268 E L H K E S K T R D D W L V S
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P97313 4128 471369 T3268 E M H K E S K T R E I W R V Q
Rat Rattus norvegicus NP_001101797 2098 241314 T1304 Y D F T P T Q T S V E R S S F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514950 4153 474137 T3294 D L H R E S K T K D D W L V R
Chicken Gallus gallus Q8QGX4 4134 472639 T3275 G L R R E A K T R E D W L V R
Frog Xenopus laevis Q9DEI1 4146 473487 T3290 D L H R E S K T N E D W S V K
Zebra Danio Brachydanio rerio XP_001919588 4119 467204 I3267 E L H R H A K I D D A R L L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781813 1817 205237 A1023 R I T S L L K A L D H L G K L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.5 N.A. N.A. 79.1 39.2 N.A. 74.1 68.8 64 58.5 N.A. N.A. N.A. N.A. 20.8
Protein Similarity: 100 99.8 98.8 N.A. N.A. 88.7 44.7 N.A. 85.4 82.5 79.8 76.1 N.A. N.A. N.A. N.A. 31.6
P-Site Identity: 100 100 100 N.A. N.A. 66.6 6.6 N.A. 73.3 60 60 40 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 100 N.A. N.A. 80 26.6 N.A. 93.3 80 80 60 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 20 0 10 0 0 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 20 10 0 0 0 0 0 0 10 60 60 0 0 0 0 % D
% Glu: 50 0 0 0 70 0 0 0 0 30 10 0 0 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % G
% His: 0 0 70 0 10 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 10 0 0 0 0 0 10 0 0 10 0 0 0 0 % I
% Lys: 0 0 0 40 0 0 90 0 10 0 0 0 0 10 10 % K
% Leu: 0 70 0 0 10 10 0 0 10 0 0 10 60 10 10 % L
% Met: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 10 % Q
% Arg: 10 0 10 40 0 0 0 0 50 0 0 20 10 0 30 % R
% Ser: 0 0 0 10 0 60 0 0 10 0 0 0 20 10 30 % S
% Thr: 0 0 10 10 0 10 0 80 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 10 0 0 0 70 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 70 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _